On June 8, 2011, the FDA issued a MedWatch alert recommending that prescribers limit the use of simvastatin 80mg. Simvastatin is also know by the brand name Zocor® and is one of the medicines in Vytorin®. The FDA stated that people taking 80mg of simvastatin (which is the highest dose available) may have an increased risk of muscle damage. Because of this risk, people who do not currently take 80mg of simvastatin should not start taking this amount. People who cannot get their cholesterol levels low enough with simvastatin 40mg should consider trying another cholesterol-lowering medicine instead of simvastatin 80mg.
This is not the first warning the FDA has given on this issue. Another MedWatch alert was issued in March 2010 with similar warnings. At that time, no recommendation was made to limit the use of the high-dose simvastatin.
Based on the findings and recommendation issued by the FDA, DestinationRx will remove all doses of simvastatin 80mg from our therapeutic alternatives engine including:
- Simvastatin 80mg
- Zocor 80mg
- Vytorin 10/80mg